Hypersensitivity. Severe destabilization of diabetes w/ either pre-coma or ketoacidosis; renal insufficiency w/ increased blood creatinine levels or decreased CrCl <60 mL/min; acute conditions w/ the potential to alter renal functions eg, dehydration, severe infection, use of iodinated contrast media; elective major surgery; disease that cause tissue hypoxia eg, cardiac failure, recent MI, shock, resp insufficiency; acute alcohol intoxication, alcoholism; liver impairment.